E2P Simulator
E2P Simulator
E2P Simulator estimates the real-world predictive utility of research findings by accounting for measurement reliability and outcome base rate. It is designed to help researchers interpret findings and plan studies across biomedical and behavioral sciences, particularly in individual differences research, biomarker development, predictive modelling, and precision medicine/psychiatry.
See Get Started guide for more details.
Developed by Povilas Karvelis
Accuracy: 0.00
Sensitivity: 0.00
Specificity: 0.00
BA: 0.00
PPV: 0.00
NPV: 0.00
F1: 0.00
MCC: 0.00
LR+: 0.00
LR-: 0.00
DOR: 0.00
P(D|+): 0.00
P(D|−): 0.00
G-Mean: 0.00
J: 0.00
Cohen’s κ: 0.00
While the interactive graph above explores a single predictor, here you can estimate the combined effect of multiple predictors and determine how many are needed to achieve a desired level of real-world predictive utility. The combined effect is estimated by first computing Mahalanobis D, a multivariate generalization of Cohen's d, which is then converted to ROC-AUC. PR-AUC is also computed to convey real-world predictive utility by accounting for the base rate. For simplicity, the estimation assumes predictors to have the same effect sizes, uniform collinearity, and no interaction effects.
Determining the right sample size is crucial for developing reliable multivariable prediction models. Too small a sample risks overfitting, unstable estimates, and poor generalizability; too large wastes resources. A common rule of thumb is to ensure a minimum number of events per variable (EPV). However, more principled criteria that are based on desired model performance - such as minimizing overfitting or prediction error - can provide more accurate estimates.
See the Get Started for more details.